Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy.
نویسندگان
چکیده
Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
منابع مشابه
Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates.
A series of novel sulfonamide substituted heteroleptic salan titanium(IV)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane ...
متن کاملCytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates - synthesis, aqueous stability and X-ray structure analysis.
Herein we report the synthesis and structural characterization of a series of novel Zr(iv)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(iv) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.
متن کاملModification of Silica surface by Titanium sol synthesis and characterization
Hydrophobic silica titanium nanoparticles (STNPs) were successfully synthesized by the sol-gel process using liquid modification. Fourier transform infrared (FTIR) and X-ray fluorescence (XRF) studies were demonstrated the attachment of titanium on the silica surface. Titanium content enhanced the agglomeration of particles as shown in topography results. The N2 adsorption-desorption followed T...
متن کاملModification of Silica surface by Titanium sol synthesis and characterization
Hydrophobic silica titanium nanoparticles (STNPs) were successfully synthesized by the sol-gel process using liquid modification. Fourier transform infrared (FTIR) and X-ray fluorescence (XRF) studies were demonstrated the attachment of titanium on the silica surface. Titanium content enhanced the agglomeration of particles as shown in topography results. The N2 adsorption-desorption followed T...
متن کاملSynthesis of Nano-Sized Titania Particles by Hydrolysis of Titanium Tetrachloride
Nano-sized titanium dioxide TiO2 powder was successfully prepared from its precursor titanium (IV) chloride by a simple and new wet chemical method. TiCl4 were used as precursor in hydrogen peroxide, H2O2 and ethanol. This solution was then peptized using nitric acid and heated under reflux at 80°C. Their physico-chemical properties were then characterized by transmission electron microscopy (T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 48 46 شماره
صفحات -
تاریخ انتشار 2012